Nurse Practitioner Chronicles

  Psychiatry & Mental Health Choosing the Right Antidepressant Just Got a Little Easier: What NPs Need to Know About the PETRUSHKA Trial A new decision-support tool helped patients stay on their antidepressant longer and feel better at six months. Here's what it means for your prescribing practice. If you've ever stared at a list of SSRIs and SNRIs wondering which one will actually work for the patient sitting across from you, you're not alone. The antidepressant selection process has long been described as "educated trial and error," and for good reason—we've had limited tools to meaningfully guide that first-line choice. A large new randomized trial published in  JAMA  in March 2026 offers some encouraging evidence that a structured, personalized approach can improve outcomes. The Study at a Glance Cipriani and colleagues conducted a multicenter RCT across 47 sites in Brazil, Canada, and the UK, enrolling 540 adults aged 18–74 with major depressive disor...

  Clinical Updates · Cardiology The 2026 ACC/AHA Dyslipidemia Guidelines: Everything Primary Care NPs Need to Know Right Now A comprehensive clinical breakdown of the most significant cholesterol guideline update in nearly a decade. Published April 2026 · NP Chronicles · 12-minute read · Updated from the 2018 ACC/AHA Guideline The 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia dropped this spring — and if you manage patients with cardiovascular risk in primary care, this one is going to change your practice. Here's what you need to know, translated for the clinic floor. Whether you're seeing a 45-year-old with a new diabetes diagnosis, a 58-year-old post-MI patient not at LDL goal, or a young woman with a family history of premature heart disease, the 2026 guidelines give us clearer targets, updated risk tools, and several entirely new recommendations that simply didn't exist before. Let's break it down. 📋 Quick Cont...