DoxyPEP in 2026: What Every NP Needs to Know About Prescribing, Patient Selection, and Antibiotic Stewardship
NFECTIOUS DISEASE | STI PREVENTION & SEXUAL HEALTH June 2026 | NP Chronicles Clinical Education DoxyPEP in 2026: What Every NP Needs to Know About Prescribing, Patient Selection, and Antibiotic Stewardship By Valerie Watters-Burke, DNSc, MSN, MBA, FNP-BC, GNP-BC, PPCNP-BC Based on: Bacic Lima D. DoxyPEP in 2026: Who Benefits, How to Prescribe, and What to Watch. Infectious Disease Special Edition. April 23, 2026. idse.net CLINICAL BOTTOM LINE DoxyPEP — doxycycline 200 mg taken within 72 hours after unprotected sexual exposure — is now CDC-endorsed, evidence-backed, and increasingly part of routine STI prevention practice for MSM and transgender women who have sex with men. NPs in primary care, sexual health, family practice, telehealth, and urgent care settings are encountering patients who have already heard of it and want to discuss it. This post gives you everything you need: the trial data, candidacy crit...